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One of the most important neurotransmitters associated with reward responses, both after they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight naturally can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight reduction and the people who go through it you need to err assisting caution and permit the FDA do its job and demand some investigation be done in order that the public knows the side effects and hazards of the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on their medications. Researchers found that participants using this drug for any year, lost excess weight within four weeks and have kept the weight off during the entire 56 weeks with the study. Contrave is a combination in the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of several active ingredient, which might make them more potent and safer. Combo-pilling could be the newest fad or also the newest ahead under scrutiny and thus it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that at the time of right now there are no long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug also can raise blood pressure level and pulse rate, and mustn't be used in those with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure, along with by a person with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking. A pyromaniac, with both psychiatric and medical therapy, can still be treated. It is best done with behavioral therapy. Psychotherapy treatment alongside behavior modification is regarded as the frequently used treatment. Based on the study of Jon Grant, a mixture treatment of drugs and behavioral therapy was discovered to be successful for pyromania. The use of serotonin reuptake inhibitors is also beneficial in manipulating the impulsive behavior from the patient as in other impulse control disorder. Also ideal for the patient are medications such as Lithium, naltrexone, (ReVia), fluoxetine (Prozac), citalopram (Celexa), paroxetene (Paxil), as well as other antidepressants.