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Contrave is often a combination with the drugs naltrexone and bupropion, which generally seems to reflect a brand new trend of weight-loss drugs which are made up of several active ingredient, which can make them far better and safer. Combo-pilling will be the newest fad or in addition to this the newest to come under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular will be the fact that at the time of right now there are no long term prescription weightloss pills that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be licensed by the FDA. Seizures are a side effect with Contrave and shouldn't be taken in people with seizure disorders. 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